Job Description

Our large pharmaceutical client is seeking a Sr. Principal Scientist, Cellular & Mechanistic Pharmacology to join their growing team in Spring House, PA as a permanent full-time employee. The Discovery Technologies & Molecular Pharmacology (DTMP) team within Therapeutics Discovery contributes to the progression of drug discovery projects from target identification to clinical development. We're looking for a talented scientist with an immunology background, deep expertise in disease biology and cellular pharmacology, and a passion for finding innovative therapeutics to treat diseases with high unmet medical need. Key Responsibilities Include:

• Lead development of innovative cell-based assays for immunology-focused projects to identify and evaluate targets, and to progress hits and lead molecules.
• Act as a key liaison between DTMP and program teams, driving project strategy and execution, in partnership with cross-functional colleagues.
• Lead efforts to combine translational and mechanistic assays with biosignature approaches and novel AI/ML methods to reveal new biology and pharmacology.
• Manage and mentor lab scientists and contribute to the cellular and mechanistic pharmacology portfolio.
• Analyze and present data at program team meetings, in-house seminars, leadership meetings and external scientific conferences, and publish research in high-quality journals.

Qualifications

• Ph. D. in Immunology, Cell Biology or equivalent with post-doctoral experience
• Minimum of 10 years of experience developing and applying novel cellular assays in a pharmaceutical industry/biotech setting
• Experience managing immunology-focused drug discovery programs across diverse modalities, in an industry setting.
• Deep expertise and proven accomplishments in immunology cellular pharmacology assay development, complex immune cellular models and high-throughput technology platforms.
• Experience with generating and culturing translationally relevant cell models such as iPSC-derived cells, primary cells, and/or co-cultures.
• Expertise collecting and analyzing data using high dimensional approaches such as high content imaging, flow cytometry and/or RNAseq.

Salary Range : $150,000-$200,000 + 20% Bonus

Hours: Monday-Friday, 8:00am-5:00pm

Hiring Method: Full-time, permanent opportunity

Benefits Include: Competitive Plans for Insurance, Retirement, PTO, Leave, Tuition Reimbursement, Commuter Benefits, Professional Development as well as Income Protection.

Exact compensation may vary based on several factors, including skills, experience, and education. Benefit packages for this role will start on the 31st day of employment and include medical, dental, and vision insurance, as well as HSA, FSA, and DCFSA account options, and 401k retirement account access with employer matching. Employees in this role are also entitled to paid sick leave and/or other paid time off as provided by applicable law.

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